Serotonin antagonist and reuptake inhibitors may sound like a difficult mouthful of medical words but are more commonly known as antidepressants. Common brands of serotonin antagonist and reuptake inhibitors include trazodone. SARIs are used mainly to treat major depressive disorder in adults. They are sometimes offered for the treatment of insomnia for patients who dislike the dizzying effects of other sleep medications. SARIs are non-narcotic.